Samit Patel took 4-5 from his four overs as the Qalandars restricted Quetta to 98/9 and won by eight wickets - just their second success of the season.
Karachi Kings, with Babar Azam and Alex Hales leading their batting, have own three games this season but were frustrated by the rain in their most recent match.
After stunning defending champions Quetta Gladiators last time out, Lahore Qalandars now take on Karachi Kings at the Gaddafi Stadium.
Lahore Qalandars vs Karachi Kings match prediction
Lahore Qalandars take on Karachi Kings at the Gaddafi Stadium, Lahore, as the Pakistan Super League action continues. The match takes place on March 8 and the live action is scheduled to start at 19:00 local time.
Lahore earned just their second win of the season last time out, with Samit Patel in superb bowling form. He took 4-5 from his four overs as Quetta struggled to 98/9 and Lahore won by eight wickets inside 12 overs.
Karachi Kings were frustrated by the rain in their most recent match, but they had won two in a row before that with Babar Azam and Alex Hales in the runs and Mohammad Amir showing good form with the ball.